Osphena® (ospemifene) – Moderate to severe vaginal dryness and/or painful intercourse due to menopau, Osphena® (ospemifene) is the first and only FDA-approved, once-daily, oral, non-hormonal treatment to treat both moderate to severe vaginal dryness and/or painful intercourse, symptoms of changes in and around your vagina due to menopause. See Important Safety Information and Boxed Warning about endometrial cancer and cardiovascular disorders.